Liver Fibrosis Treatment in India
Liver fibrosis occurs when the healthy tissue of your liver becomes scarred and cannot work as well. Fibrosis is the first stage of liver scarring. Some fibrosis can be reversible.
Scarring of the liver occurs on a spectrum, with different degrees. Some of them may be treatable and reversible. However, medications and lifestyle changes can help to keep fibrosis from getting worse.
What are the causes of liver fibrosis?
Liver fibrosis occurs after a person experiences injury or inflammation in the liver. The liver’s cells stimulate wound healing. During this wound healing, excess proteins such as collagen and glycoproteins build up in the liver.
Eventually, after many instances of repair, the liver cells (known as hepatocytes) can no longer repair themselves. The excess proteins form scar tissue or fibrosis.
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What are the stages of liver fibrosis?
There are several different scales of liver fibrosis staging, where a doctor determines the degree of liver damage. This may be achieved with a variety of methods, such as blood work, imaging tests, and a tissue biopsy that may be further examined under a microscope (histology).
But a doctor will need to diagnose any underlying chronic liver disease, such as fatty liver disease or hepatitis. This can help identify the underlying causes of inflammation that lead to fibrosis, and better guide the staging and treatment process.
While fibrosis staging can help you and a doctor understand the degree to which your liver might be damaged, it’s important to note that identifying the underlying cause is more important than focusing on any particular stage.
If a liver biopsy and histology is performed, a doctor may stage liver fibrosis based on the METAVIR scoring system.
This assigns a “score” based on two factors: inflammation (activity) and damage (fibrosis). A lower score may indicate less inflammation and damage, while a higher score could mean more.
The activity grades range from A0 to A3:
- A0: no activity
- A1: mild activity
- A2: moderate activity
- A3: severe activity
The fibrosis stages range from F0 to F4:
- F0: no fibrosis
- F1: portal fibrosis without septa
- F2: portal fibrosis with few septa
- F3: numerous septa without cirrhosis
- F4: cirrhosis
Therefore, a person with the most severe disease form may have an A3, F4 METAVIR score.
Another scoring system based in histology is Batts and Ludwig, which grades fibrosis on a scale of grade 1 to grade 4, with grade 4 being the most severe.
The International Association of the Study of the Liver (IASL) also has a histological scoring system with four categories that include:
- Minimal chronic hepatitis
- Mild chronic hepatitis
- Moderate chronic hepatitis
- Severe chronic hepatitis
Fibrosis staging may also be based on other tests outside of a liver biopsy and histology. For example, a doctor may confirm liver fibrosis with a blood test that measures fibrosis 4 (Fib4) in the blood.
could mean you’re at a high risk for liver fibrosis.
Additionally, fibrosis staging may be confirmed with the help of imaging tests. These look at the size and shape of your liver, as well as for excess fat, lumps, or shrinkage. Possible imaging study techniques include:
- abdominal ultrasound
- computed tomography (CT) scan of your abdomen
- magnetic resonance imaging (MRI) scan
- elastography, which is combined with either an ultrasound or MRI scan
Treatment:
Treatment options for liver fibrosis usually depend upon the underlying cause of the fibrosis. A doctor will treat the underlying illness, if possible, to reduce the effects of liver disease.
For example, if a person drinks alcohol excessively, a doctor may recommend a treatment program to help them stop drinking. If a person has NAFLD, a doctor may recommend making dietary changes to lose weight and taking medications to promote better blood sugar control.
Exercising and losing weight may also help to reduce the disease’s progression.
Treatments for specific causes of liver fibrosis include:
- chronic liver disease:ACE inhibitors such as benazepril Lisinopril and ramipril
- hepatitis C virus: direct action antivirals such as Epclusa, Harvoni, Mayvret, etc.
- nonalcoholic steatohepatitis: PPAR-alpha agonist
- autoimmune hepatitis: immunosuppressive therapy
- alcohol liver disease: abstinence from alcohol
A doctor may also recommend antifibrotics that may possibly help reduce the likelihood of permanent liver scarring (cirrhosis). Depending on the drug, antifibrotics are classified as:
- anti-inflammatories: examples include bela pectin, cenicriviroc, and liraglutide
- hepatocyte apoptosis inhibitors: these include emricasan, pentoxifylline, and selonsertib
- oxidative stress inhibitors: possibilities include methyl ferulic acid and losartan
- hepatic stellate cell (HSC) inhibitors: these drugs target various cytokines that may activate HSCs
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- and contribute to fibrosis
Still, there are limitations to antifibrotic treatment. While some of the above medications are used for other purposes, such as high blood pressure and vascular diseases, not all are yet approved for the treatment of liver fibrosis. Animal studies show promise, but human clinical trials are limited.
If a person’s liver fibrosis advances to where their liver is very scared and doesn’t work, a person’s only definitive treatment is often to receive a liver transplant. However, the waiting list is long for these transplant types and not every person is a surgical candidate.
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Max Hospital Saket
Number of beds: 500
ICU Beds: 267
Airport Distance: 13 KM
Brief About:
- Max Super Speciality Hospital at Saket is one of the topmost healthcare service
- Providers in India. The multi-super speciality hospital has a capacity of over 500 beds, 250 functional beds. It is equipped with state-of-the-art facilities, advanced technologies.
- With the help of over 300 leading specialist Doctors, strong nursing staff, and state-of-the-art innovative medical tools.
Fortis Memorial Research Institute
Number of beds: 1000
ICU Beds: 298
Airport Distance: 17 KMs
Brief About:
- Fortis Memorial Research Institute was established in 2001.
- It is an outstanding multi-speciality quaternary care hospital,having the top-notch infrastructure, advanced equipment, highly qualified and experienced medical professionals and super sub-specialists.
- Fortis Hosptial Gurgaon is an advanced centre of excellence in Robotic Surgery, Neurosciences, Oncology, Renal Sciences, BMT, Organ Transplants, Orthopaedics, Cardiac Sciences and Obstetrics & Gynaecology.
Artemis Hospital Gurgaon
Number of beds: 600
ICU Beds: 185
Airport Distance: 19 Km
Brief About:
- Artemis Hospital, established in 2007, spread across 9 acres, is a 600plus bed; state-of-the-art multi-speciality hospital located in Gurgaon, India.
- Artemis Hospital is the first JCI and NABH accredited hospital in Gurgaon.
- Designed as one of the most advanced hospitals in India, Artemis provides a depth of expertise in the spectrum of advanced medical & surgical interventions, a comprehensive mix of inpatient and outpatient services.
Manipal Hospital Dwarka
Number of beds: 380
ICU Beds: 118
Airport Distance: 8 Km
About Hospital:
- Manipal Hospital Dwarka is a prominent multi-speciality and quaternary care providing hospital with first-rate healthcare services and integrated facilities.
- The world-class medical centre is a part of Manipal Education and Medical Group (MEMG), one of India’s forerunner healthcare groups.
- The group started with one flagship hospital in 1991 and now has bloomed into a network of 15 hospitals with a significant presence in Malaysia.
Indraprastha Apollo Hospital
No. of beds: 900
ICU Beds: 262
Airport: 20kms
About Hospital:
- Indraprastha Apollo Hospital is a flagship hospital of India’s foremost healthcare groups,the Apollo Group. It is a highly renowned multi-speciality facility that offers tertiary and quaternary care services to domestic and international patients.
- The 900 bedded hospital is outfitted with the most modern technology for diagnostics as well as therapeutic purposes.
- A team of highly trained medical professionals work under all the 52 specialities at the hospital.
Medanta The Medicity Hospital
Number of beds: 1250
ICU Beds: 300
Airport Distance: 18 KMs
Brief About:
- Medanta – The Medicity is amongst India’s largest and most renowned multi-super speciality healthcare centre with 1250 beds, 29 super speciality units and more than 800 accomplished doctors.
- Supported by state-of-art infrastructure, all the departments in the hospital are fully equipped with cutting-edge technology, modular Operation Theatre and modernized monitoring systems in ICUs.
- The panel of doctors from Medanta, headed by A.S.Soin performed the first successful intestinal transplant in India.
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BLK-Max Hospital
Number of beds: 700
ICU Beds: 175
Airport Distance: 13 Km
Brief About:
- BLK Super Speciality Hospital was established by Dr. B.L. Kapur in 1959. It was inaugurated by the then Prime Minister of India, Pandit Jawahar Lal Nehru.
- BLK Super Speciality Hospital was established by Dr. B.L. Kapur in 1959. It was inaugurated by the then Prime Minister of India, Pandit Jawahar Lal Nehru.
- BLK has a unique combination of the best in class technology, put to use by the best names in the professional circles to ensure world-class health care to all patients.
Dr. Rela Institute and Medical Centre
Number of beds: 450
ICU Beds: 130
Airport Distance: 8 KMs
About Hospital:
- Dr. Rela Institute & Medical Centre was established under the leadership of Prof. Mohamed Rela, a world-renowned surgeon in the field of Liver Surgery and Transplantation.
- Dr. Rela made a world-record by performing a Liver Transplantation on a 5-day old baby and made his name in the Guinness Book of Records.
- Dr. Mohamed Rela, who has performed more than 4000 liver transplant surgeries.
Manipal Hospital Bangalore
Number of beds: 600
ICU Beds: 124
Airport Distance: 18 KMs
About Hospital:
- Established in the year 1991. Manipal Hospital HAL Airport Road is a multi-specialty hospital.
- The hospital has 600 in-patient beds. The NABH and NABL accredited facility is among the top 10 multispecialty hospitals in India.
- It is prominent for making use of high tech equipment and systems like IBM Watson technology for oncology patients.
Aster CMI Hospital Bangalore
Number of beds: 500
ICU Beds: 50
Airport Distance: 27 KMs
About Hospital:
- Aster CMI hospital was established in 2014, from a single medical centre to a performance driven healthcare enterprise, spread across 320 establishments in 9 countries.
- Aster CMI hospital is one of the top hospitals in Bangalore, with serene ambience, spacious interiors, advanced medical facilities.
- Aster CMI is one of the best multispecialty hospitals in Bangalore as per the Times of India (TOI) All India Multispecialty Ranking Survey.
Kokilaben Dhirubhai Ambani Hospital
Number of beds: 750
ICU Beds: 180
Airport Distance: 8 KMs
About Hospital:
- Kokilaben Dhirubhai Ambani Hospital is a top-class multi-specialty tertiary care hospital with a capacity of 750 inpatient beds.
- The hospital has a large number of ICU beds in Mumbai, with 180 ICU beds and 240 independent clinics,having the capacity to deal with over 9,000 outpatient consultations every day.
- The hospital prides itself for having a Full Time Specialist System which ensures easy access and comprehensive use of resources to various specialists .
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We offers these Services
- Providing a doctor’s opinion and proper quotation
- Selecting the best hospital and doctor as per your case
- Arranging a call with the doctor (if the case required)
- Visa assistance, Providing Visa Invitation Letter (VIL)
- Providing full guidance how to get Visa from your country
- Providing total cost including treatment, air tickets, accommodation, and food
- Assitance to book flight ticket from your country
- Arranging airport pick up/ drop
- Providing professional language interpreter
- Booking accommodation and guest house as per your budget/ prefrence
- Providing help in money exchanging
- Providing local sim card
- Arranging video consultation with specialist doctor if case requires
